产前咖啡因暴露与儿童发育之间的关联:青少年大脑认知发育 (ABCD) 研究的纵向结果
Hailey Modi1, David A A Baranger2, Sarah E Paul2
1Department of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA; Department of Psychiatry, Washington University in Saint Louis, USA.
Neurotoxicology and teratology
|November 26, 2024
概括
每日产前咖啡因暴露与更高的儿童体重指数 (BMI) 和青少年睡眠问题增加有关. 需要进一步的研究来了解怀孕期间咖啡因摄入量与儿童健康结果之间的因果关系.
科学领域:
- 生殖健康 生殖健康
- 儿童发展 儿童发展
- 营养科学 营养科学
背景情况:
- 怀孕期间咖啡因消费很普遍,但其对儿童发育的长期影响尚未完全理解.
- 现有的研究缺乏关于产前咖啡因暴露和随后儿童健康结果的全面纵向数据.
研究的目的:
- 在进入青春期的儿童中调查产前咖啡因暴露与体重指数 (BMI) 之间的关联.
- 为了检查产前咖啡因摄入量与儿童行为和睡眠结果之间的关系.
主要方法:
- 利用了青少年大脑和认知发展 (ABCD) 研究的纵向数据,其中包括11875名9至11岁的儿童.
- 分析了护理人员报告的产前咖啡因暴露,将其分为四个级别,并检查了"任何"和"每日"暴露组.
- 控制潜在的混因素,如收入,家庭精神病理,产前物质暴露和孩子自己的咖啡因使用.
主要成果:
- 每日产前咖啡因暴露与儿童BMI显著增加有关 (β=0.08,FDR校正 p=0.02).
- 在怀孕期间每天喝两杯或两杯以上咖啡因的儿童有更多的睡眠问题 (β>0.92,FDR校正的p<0.04).
- 在多次测试纠正后,在产前咖啡因暴露和儿童行为之间没有发现显著的关联.
结论:
- 每日产前咖啡因摄入与儿童BMI升高和儿童睡眠障碍增加有关.
- 这项研究强调了母体咖啡因消费对身体和睡眠健康的潜在影响.
- 将产前咖啡因暴露与这些结果联系在一起的确切因果机制需要进一步研究.
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