对左前额叶皮层的间歇性达爆发刺激可以增强灭绝学习,但不能提醒灭绝
Lisa M Cybinski1, Sophia Hüsch1, Georg C Ziegler1
1Center of Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Wuerzburg, Margarete-Hoeppel-Platz 1, Wuerzburg 97080, Germany.
Behavioural brain research
|November 26, 2024
概括
对左后PFC应用的间歇性达爆发刺激 (iTBS) 并没有增强恐惧灭绝记忆的巩固. 需要进一步的研究来优化潜在的临床应用的参数.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 左腹中中前额叶皮质 (vmPFC) 的非侵入性脑刺激显示出增强恐惧灭绝的潜力.
- 临床使用的最佳刺激参数尚未确定.
研究的目的:
- 通过使用三天的范式,研究间歇性达爆发刺激 (iTBS) 对恐惧灭绝的影响.
- 评估iTBS在灭绝学习,自发恢复和恢复测试期间对恐惧反应的影响.
主要方法:
- 50名健康参与者接受了恐惧获取,灭绝学习和恢复/恢复测试.
- 在灭绝学习之前,主动或假 iTBS 应用于左后PFC.
- 通过皮肤导电性反应 (SCR) 和主观评分来测量恐惧反应.
主要成果:
- 与假冒相比,在活跃的iTBS组中,显著的时间x组相互作用表明在灭绝学习期间SCR减少.
- 在自发恢复或恢复测试中没有观察到iTBS的显著影响.
结论:
- 针对左后PFC的iTBS证明了增强恐惧灭绝记忆巩固的有限治疗潜力.
- 需要进一步的研究来确定临床疗效的最佳刺激参数.
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