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Updated: Jun 6, 2025

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一个超分子蛋白质组合本质上拯救了阿尔茨海默病小鼠模型中的记忆缺陷

Yuchong Hao1, Xin Shen1, Jiantao Liu2

  • 1Sino-German Joint Research Lab for Space Biomaterials and Translational Technology, Synergetic Innovation Center of Biological Optoelectronics and Healthcare Engineering, School of Life Sciences, Northwestern Polytechnical University, Youyi West Road 127, Xi'an, Shaanxi 710072, China.

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|November 26, 2024
PubMed
概括

研究人员开发了一种新型的超分子蛋白组件,能够穿越血脑屏障 (BBB). 这种纳米光盘技术有效地针对阿尔茨海默病的病理学,并改善了小鼠模型中的认知功能.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.血脑屏障是什么意思一个纳米光盘.纳米医药是一种纳米医药.蛋白质组合组件的组合

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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