侧侧脑内皮层神经元,这些神经元投射到 nucleus accumbens 中介语境关联记忆
Hayley M Kuhn1, Luis Colon Serrano2, Grace A Stys3
1Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA andrew.eagle@utdallas.edu.
Learning & memory (Cold Spring Harbor, N.Y.)
|November 26, 2024
概括
侧侧脑内皮层 (LEC) 到核 (NAc) 的通路对于形成积极和消极背景的记忆至关重要. 禁用此电路会损害内存编码,但不能恢复.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 记忆研究 记忆研究
背景情况:
- 侧侧脑内皮层 (LEC) 投射到内核 (NAc).
- 这个途径可能参与编码情感价值的上下文关联 (例如,药物线索,恐惧).
研究的目的:
- 研究LEC-NAc神经元在编码和回忆与积极 (可卡因) 和消极 (足震) 经验相关的背景中的作用.
- 为了确定LEC-NAc神经元激活是否特定于编码或价值.
主要方法:
- 测量了LEC-NAc神经元中的c-fos表达,在暴露于与可卡因或足震相关的新鲜和重新暴露的环境后.
- 在记忆编码和检索阶段利用电路特定的化学遗传学来禁用LEC-NAc神经元.
- 采用行为测试来评估记忆形成和回忆.
主要成果:
- LEC-NAc神经元在新的和重新暴露的环境中都被激活,这表明它在编码中发挥了作用,而不是价值.
- 在编码过程中,LEC-NAc神经元的化学遗传性失活会损害积极和消极的背景相关记忆的形成.
- 已建立的记忆检索不受LEC-NAc神经元失活的影响.
结论:
- 对于上下文关联的初始编码,LEC-NAc神经元至关重要.
- 这个电路指导与学习背景相关的动机行为.
- LEC-NAc途径促进记忆编码,但不会直接调解相关记忆的享乐或厌恶性质.
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