免疫检查点抑制剂的神经并发症:一本实用指南
Aisling S Carr1,2, Frederick William Vonberg2,3, Shiwen Koay4,2
1Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK Aisling.carr@nhs.net.
Practical neurology
|November 26, 2024
概括
免疫检查点抑制剂 (ICI) 增强抗癌免疫力,但可能导致罕见的严重神经毒性. 随着ICI使用的扩大,管理这些不良事件需要多学科的专业知识.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 免疫检查点抑制剂 (ICI) 如CTLA-4,PD-1,PD-L1和LAG-3阻断T细胞抑制,增强抗瘤免疫力.
- ICI可以改善各种癌症的存活率,包括转移性黑色素瘤,但可以导致与免疫相关的不良事件 (irAEs).
研究的目的:
- 描述ICI作用机制及其对癌症结果的影响.
- 专注于ICI诱导的神经毒性的发生率,临床表现和管理.
主要方法:
- 审查ICI机制,临床结果和irAEs.
- 专注于神经毒性,合成临床专业知识和管理策略的共识.
主要成果:
- ICI显著改善癌症存活率,但可能导致瘤外的瘤毒性.
- ICI神经毒性很罕见但严重,呈现出多样化和急性神经系统综合征.
结论:
- ICI治疗提供了显著的瘤益处,但需要仔细管理irAEs.
- 管理ICI神经毒性的专业知识是至关重要的,因为它的严重程度和免疫疗法的使用越来越多.
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