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Updated: Jun 24, 2026

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陶积累诱导阿尔茨海默病模型小鼠微质状态的改变

Kenichi Nagata1,2, Shoko Hashimoto2,3, Daisuke Joho4

  • 1Department of Functional Anatomy and Neuroscience, Nagoya University, Graduate School of Medicine, Aichi 466-8550, Japan knagata@med.nagoya-u.ac.jp hiroki.sasaguri@riken.jp.

eNeuro
|November 26, 2024
PubMed
概括

阿尔茨海默氏症 (AD) 病理改变了微质状态,促进了与疾病相关的微质. 这项研究揭示了TAU在一种新的AD小鼠模型中对微质表型的影响,进步了我们对AD病原学的理解.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.粉样蛋白-β-β 的存在.微质细胞中的微质细胞一个单细胞RNA-seqq.知道了,就知道了.

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...