糖尿病视网膜病变和牙周炎:系统性审查和元分析的含义
Sukumaran Anil1, Betsy Joseph2, Merlyn Anjali Pereira3
1Oral Health Institute, Hamad Medical Corporation, Doha, Qatar; College of Dental Medicine, Qatar University, Doha, Qatar.
International dental journal
|November 26, 2024
概括
患有严重牙周炎的糖尿病患者患上糖尿病视网膜病变 (DR) 的几率明显更高. 然而,证据质量较低,需要进一步的高质量研究来证实这一关联.
科学领域:
- 内分泌学和代谢障碍 代谢障碍
- 眼科医生 眼科 眼科
- 牙周病学 牙周病学
背景情况:
- 糖尿病是一种全球性健康问题,与糖尿病视网膜病变 (DR) 和牙周炎等微血管并发症有关.
- 牙周病和牙周炎之间的相互关系需要进一步调查,以改善患者的治疗.
研究的目的:
- 系统地审查和分析1型和2型糖尿病患者糖尿病视网膜病变和牙周炎之间的关联.
- 评估当前关于这两个条件之间的联系的证据.
主要方法:
- 在多个数据库 (PubMed/MEDLINE,Scopus,EMBASE,Google Scholar,Web of Science) 中进行了全面的搜索.
- 包含1828名参与者的10项研究用于定性综合,偏差风险评估 (ROBINS-E,GRADE) 和随机效应元分析.
- 该PECO框架指导了研究选择过程.
主要成果:
- 十项研究中有八项表明严重牙周炎 (口袋深度≥5毫米) 和DR之间存在显著联系.
- 分析显示,患有牙周炎的糖尿病患者患有视网膜病变的几率是4.48倍 (P = .003).
- 观察到很高的异质性 (I2 = 86%),总体的GRADE证据水平非常低.
结论:
- 大多数研究表明,严重牙周炎和增加的牙周病风险之间存在联系,但证据的确定性很低.
- 牙周健康可能在治疗糖尿病患者中发挥作用.
- 需要高质量的纵向研究来确定因果关系,并了解牙周炎和DR进展之间的关系.
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