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比较三维零回声时间 (3D-ZTE) 肺部MRI和胸部CT在评估系统性硬化症相关的间歇性肺部疾病

Furkan Ufuk^1,2, Burak Kurnaz³, Hakki Peker³

¹Department of Radiology, Pamukkale University School of Medicine, Denizli, Turkey. furkan.ufuk@hotmail.com.

European radiology

|November 26, 2024

概括

三维零回声时间 (3D-ZTE) MRI为系统性硬化症 (SSc) 患者评估间歇性肺病 (ILD) 提供了可靠的,无辐射的替代方案. 这种MRI技术与用于ILD评估的CT扫描有很强的相关性,使得长期监测更安全.

科学领域:

放射学放射学是一门学科.
肺部病理学肺部病理学
医疗成像医学成像

背景情况:

系统性硬化症 (SSc) 经常导致间歇性肺病 (ILD),这是预后不佳的重要预测因素.
由于对连续CT扫描累积辐射暴露的担忧,需要在SSc中进行ILD评估的替代成像方式.
三维零回声时间 (3D-ZTE) MRI为评估SSc.肺部参与提供了一个有希望的无辐射选择.

研究的目的:

评估3D-ZTEMRI在评估SSc相关ILD中的有效性.
为了比较3D-ZTEMRI与薄切片胸部CT在量化ILD程度方面的性能.
通过3D-ZTEMRI测量ILD程度和肺功能测试 (PFTs) 之间的相关性.

主要方法:

一项前性单中心研究包括65名SSc患者,他们接受了CT,3D-ZTE肺部MRI和PFTs.
三位独立审查员在CT和3D-ZTEMRI图像上视觉量化了ILD的程度.
统计分析包括类内相关系数 (ICC),克鲁斯卡尔-瓦利斯测试,布兰德-阿尔特曼分析和与PFT相关性分析.

主要成果:

在CT诊断的91.1%患者中,3D-ZTEMRI检测到ILD,在评估ILD严重程度方面显示出强烈的相关性 (r=0.986,p<0.001).
中位数ILD程度得分相似:CT为5%,3D-ZTEMRI为6%.
在3D-ZTEMRI中观察到卓越的观察者间可靠性 (ICC:0.853-0.969),ILD程度和肺功能 (例如,FVC) 之间存在显著的负相关性.

结论:

3D-ZTEMRI是胸部CT的可靠且无辐射的替代方案,用于评估SSc相关的ILD.
该技术在评估纤维化和磨砂玻璃不透明度方面与CT有很强的一致性.
虽然有效,3D-ZTEMRI在检测ILD模式的细网状和粗度方面存在局限性.

关键词:

计算机断层扫描 (CT) 是一种计算机断层扫描.间歇性肺病间歇性肺病呼吸功能测试呼吸功能测试系统性硬化症系统性硬化症零回声时间磁共振成像

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