卵巢癌的神经上皮质起源是通过表皮-介质细胞-外皮过渡来解释的,这种过渡得到了cisplatin的加强
David Díaz-Carballo1, Ayesha Safoor2, Sahitya Saka3
1Institute of Molecular Oncology and Experimental Therapeutics, Division of Hematology and Oncology, Ruhr University Bochum Medical School, Marien Hospital Herne, Düngelstr. 33, 44623, Herne, Germany. david.diaz-carballo@marienhospital-herne.de.
Scientific reports
|November 26, 2024
概括
卵巢癌细胞在接受西斯治疗时经历了一种新的上皮-介质-外皮过渡 (EMET),发展神经特征和多药性耐药性 (MDR). 这表明卵巢癌的神经皮质干细胞起源.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
背景情况:
- 对衍生物化疗的获得性耐药性是治疗卵巢癌的一个重要障碍.
- 了解细胞可塑性和卵巢癌的起源对于开发有效疗法至关重要.
研究的目的:
- 为了研究卵巢癌对西斯普拉丁治疗的细胞反应.
- 确定驱动卵巢癌进化和耐药性的细胞的起源和特征.
主要方法:
- 在用西斯普拉丁治疗的卵巢癌细胞中分析表皮-介质细胞过渡 (EMT) 标记物和神经元标记物.
- 卵巢癌细胞与神经/干细胞和多药耐药性 (MDR) 现型的分离和特征.
- 培养卵巢癌细胞作为有机体,观察形态变化.
- 在正常卵巢组织中识别和表征类似细胞群.
主要成果:
- 西斯普拉丁治疗在卵巢癌细胞中诱导了上皮-介质-外皮过渡 (EMET),其特征是上皮标记物的下调,维丁的上调以及胚胎和神经元标记物的表达.
- 分离了具有双神经/干细胞特征和MDR表型的细胞,并观察到上皮细胞与这些群体有差异.
- 神经元形态迅速诱导在卵巢癌细胞培养为有机体.
- 在正常的卵巢组织中发现了一种具有神经/干细胞特征的独特细胞类型,并且在卵巢瘤中被发现被放大,这表明它具有神经上皮原点.
结论:
- 卵巢癌很可能起源于具有内在神经/干细胞特征和MDR特征的小细胞亚群.
- 已确定的EMET过程和神经皮质干细胞群是卵巢癌发展和治疗耐药性的关键因素.
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