在儿童血液学和瘤学部门实施两步抗菌药物管理计划的影响
Cecilia Liberati1, Elisa Barbieri2, Francesca Cavagnero2
1Division of Paediatric Infectious Diseases, Department of Women's and Children's Health, University of Padova, Via Giustiniani 3 Padua, 35141, Padova, Italy. cecilia.liberati@unipd.it.
Scientific reports
|November 26, 2024
概括
实施多步骤的抗菌药物管理计划显著减少了小儿血液瘤患者的抗生素使用. 这种方法优化了指导方针的遵守,并减少了这个弱势群体的过度处方.
科学领域:
- 儿科血液瘤学
- 抗微生物药物管理委员会
- 传染病管理 传染病管理
背景情况:
- 血液瘤学和干细胞移植 (HSCT) 患者有感染的高风险.
- 优化抗微生物药物的使用对于打击耐药性和改善患者的治疗结果至关重要.
研究的目的:
- 描述一个多步骤的抗微生物管理计划的实施.
- 评估干预措施对儿童血液瘤病房抗生素消费的影响.
主要方法:
- 一项前后准实验性研究,中断时间序列分析 (01/01/201931/12/2022).
- 干预措施包括传播发烧性中性质的临床途径和一个定制的应用程序,具有前性审计和反.
- 抗生素消耗量以治疗日 (DOT) / 1000 个患者日来衡量.
主要成果:
- 第一个干预措施 (临床途径) 降低了整体抗生素的使用,使得比第三代头素更喜欢皮佩拉西林-塔扎巴克坦.
- 第二次干预 (管理计划) 进一步减少了总抗生素消耗.
- 观察到梅罗,阿米卡辛和糖类的使用量显著下降.
结论:
- 一个多步骤的管理计划,包括指南传播和多学科合作,有效地优化了抗菌素的使用.
- 该计划在改善指导方针的遵守和减少脆弱患者队列中过度处方抗生素方面表现出高效.
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