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在血小板制备,储存和输血反应中识别新的生物活性分子,以改善输血管理

Anne-Claire Duchez^1,2, Charles-Antoine Arthaud^3,4, Marie-Ange Eyraud^3,4

¹Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France. Anne-Claire.DUCHEZ@efs.sante.fr.

Scientific reports

|November 26, 2024

概括

血小板缩物 (PC) 中的生物标志物可以预测输血不良反应 (AR). 增加的NGAL,HSAA和GDF-15表明AR风险更高,而减少的MDC和CX3CL1表明潜在的安全性.

科学领域:

输血医学输血医学
免疫学免疫学免疫学
生物化学生物化学

背景情况:

血小板缩剂 (PC) 含有生物活性分子,包括生物响应修饰剂 (BRM).
PC 中的白细胞衍生分子可以影响输血结果和不良反应 (AR).

研究的目的:

调查不同PC制剂储存期间特定生物标志物的变化.
为了确定预测与PC输血相关的AR的潜在生物标志物.

主要方法:

在单个捐赠者非性PC (SDA-PC) 和布菲外套PC (BC-PC) 中分析NGAL,GDF-15,MIP1α,MCP-3,HSAA,MDC和CX3CL1水平.
与ARs相关的PC中生物标志物水平的比较与没有ARs的PC.

主要成果:

在SDA-PC储存期间NGAL和GDF-15增加;MIP1α,MCP-3和HSAA在BC-PC中增加,而GDF-15则下降.
接受AR输血的PC患者显示NGAL,HSAA和GDF-15水平显著升高.
与非AR病例相比,接受AR输血的PC患者的MDC和CX3CL1水平显著降低.

结论:

特定的生物标志物在PC存储期间发生变化,根据制剂类型而异.
NGAL,HSAA,GDF-15,MDC和CX3CL1水平可以作为PC相关不良反应的预测指标.

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