在注意力缺陷/多动症障碍的未使用过毒品儿童中,动态功能架构的异常稳定性
Shuangli Chen1, Beihui Xue1, Ronghui Zhou1
1Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
BMC psychiatry
|November 26, 2024
概括
患有ADHD的儿童表现出大脑功能稳定性的改变,特别是在默认模式网络和突出网络中. 这些变化与认知缺陷相关,为ADHD提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一个常见的儿童神经发育障碍.
- 以前的研究表明,使用功能连接 (FC) 分析,在ADHD中出现大脑功能障碍.
- 有限的研究已经探索了ADHD儿童动态大脑网络的稳定性.
研究的目的:
- 为了研究ADHD的未使用过药物的儿童的功能稳定性 (FS) 异常.
- 确定受ADHD改变动态功能架构影响的特定大脑区域和网络.
- 为了将功能稳定与ADHD的认知表现相关联.
主要方法:
- 42名患有多动症和多动症的儿童和30名健康对照者的休息状态fMRI数据.
- 移动窗口方法计算基于动态FC的voxel-wise功能稳定性 (FS).
- 基于种子的动态FC (dFC) 分析,以探索特定大脑区域的变化.
- 与Stroop测试性能进行组间比较和相关性分析.
主要成果:
- 患有ADHD的儿童表现出双边上额头 (SFG) 的FS降低和右侧中 (MTG) 的FS增加,这两者都是默认模式网络 (DMN) 的一部分.
- 在SFG (DMN) 和左岛 ( Salience 网络, SN) 之间观察到增加的dFC.
- 在右MTG和左小脑后叶之间发现dFC降低;SFG FS降低与Stroop测试表现差相关.
结论:
- 在ADHD中异常的功能架构涉及DMN (SFG,MTG) 和SN (岛屿).
- 这项研究强调了ADHD儿童大脑功能网络的动态变化.
- 这些发现为ADHD的神经生物学基础提供了新的见解.
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