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Updated: Jun 6, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

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新型小分子抑制 Estrogen受体激活功能2 (ER-AF2) 的特性

Jane Foo1, Francesco Gentile1, Shabnam Massah1

  • 1Vancouver Prostate Centre, Department of Urologic Science, University of British Columbia, 2660 Oak Street, Vancouver, BC, V6H 3Z6, Canada.

Breast cancer research : BCR
|November 27, 2024
PubMed
概括

研究人员开发了一种新型化合物VPC-260724,向雌激素受体 (ER) 激活功能2 (AF2) 部位,以对抗ER阳性乳腺癌的耐药性. 这种新的ER-AF2结合剂显示出抗增殖活性,并可能提供一种补充治疗方法.

关键词:
激活功能 2 激活功能 2乳腺癌 乳腺癌 乳腺癌雌激素受体的受体是什么小分子抑制剂 小分子抑制剂

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