基于炎症的得分预测慢性病在患有慢性病和慢性心力衰竭的患者中的慢性病进展
1Department of Nephrology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Renal failure
|November 27, 2024
概括
预后营养指数 (PNI) 等炎症评分可以预测慢性病 (CKD) 在慢性病和慢性心力衰竭 (CHF) 患者中的进展. 较高的PNI分数表明CKD进展的风险更高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 炎症研究 炎症研究
背景情况:
- 炎症与慢性病 (CKD) 和慢性心力衰竭 (CHF) 的不良结果有关.
- 有限的大规模数据存在于患有这两种疾病的患者的基于炎症的评分的预后价值.
研究的目的:
- 研究CKD和CHF患者的基于炎症的得分的临床关联和预后影响.
- 为了确定炎症评分和CKD进展在这个患者队列之间的关系.
主要方法:
- 来自中国脏数据系统 (CRDS) 的8491名CKD (1-3b阶段) 和CHF患者的回顾性队列研究.
- 使用的格拉斯哥预测得分 (GPS),修改的格拉斯哥预测得分 (mGPS),预测营养指数 (PNI) 和预测指数 (PI).
- 定义CKD进展为估计膜过率 (eGFR) 的40%降低或进展到末期病 (ESRD).
主要成果:
- 较高的炎症评分 (GPS,mGPS,PNI,PI) 与增加的CKD进展率有关 (日志级别测试,p < 0.001).
- 多变量考克斯分析确定GPS (HR 1.40) 和PNI (HR 1.54) 是CKD进展的显著预测因素.
- PNI显示可接受的预后值 (C指数=0.757) 和在各个子组中与CKD进展的一致关联.
结论:
- 基于炎症的评分,特别是PNI,可以作为预测CKD进展的有价值的临床生物标志物.
- 在患有同时存在的CKD和CHF的患者中,PNI提供了一个有用的风险分层工具.
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