不同的时间限制的养模式可能会通过改变猪肠道微生物的托芬代谢来调节代谢健康
Qiuke Li1, Ding Tan1, Shijie Xiong1
1Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, China.
Food research international (Ottawa, Ont.)
|November 27, 2024
概括
限时养 (TRF) 通过改变肠道细菌和代谢物,减少肝脂肪和改善肝功能标志物来改善代谢健康. 这种方法为管理代谢障碍提供了潜在的策略.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 我们的肠道微生物群.
- 营养科学 营养科学
背景情况:
- 时间限制养 (TRF) 是一种有前途的代谢健康策略.
- TRF的潜在微生物机制尚未得到充分理解.
- 养殖猪被用作研究饮食习惯的模型.
研究的目的:
- 调查不同时间限制的养模式对猪代谢健康的影响.
- 探索肠道微生物群和代谢物的作用,以调解TRF的益处.
- 阐明TRF影响肝脏新陈代谢的分子机制.
主要方法:
- 实施了四种养模式:随意养 (ALF),时间限制养 (TRF),早期时间限制养 (eTRF) 和中午时间限制养 (mTRF).
- 进行了肝转录组分析,以评估基因表达变化.
- 进行了肠道微生物组和代谢组分析.
- 实验室内实验被用来确认微生物代谢产物的作用.
主要成果:
- 与ALF相比,TRF,eTRF和mTRF减少了肝脏脂肪积累和肝功能标志物,独立于食物摄入.
- TRF模式降低了参与葡萄糖生成,β氧化,脂质积累和尿素循环的基因.
- TRF模式调高了与脂质生成和糖解相关的基因.
- 结肠中的乳酸菌丰富与血清甘油三水平有负相关性.
- 微生物代谢物Indole-3-乳酸被TRF提升,并在体外减少肝脂积累.
结论:
- 时间限制的养通过调节肠道微生物群和代谢物来改善代谢健康.
- TRF干预可以减少肝脏脂肪的积累,改善肝脏功能.
- 印度尔-3-乳酸可能是一个关键的微生物代谢物,调解TRF对肝脂代谢的有益作用.
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