通过调节肠肝轴,减轻小鼠中D-银糖诱导的衰老,使用TY-Y10 TY-Y10的Lactiplantibacillus plantarum
Shaoqi Shi1, Xiaoxia Li1, Feng Zhang2
1Key Laboratory of Functional Dairy, Department of Nutrition and Health, Co-Constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100190, China.
Foods (Basel, Switzerland)
|November 27, 2024
概括
乳球菌植物菌TY-Y10,既可活性又可热性失活,可以对抗老化相关的小鼠氧化应激. 这种益生菌调节肠道微生物群,并激活肝脏的抗氧化途径,提供潜在的抗衰老益处.
科学领域:
- 微生物学 微生物学
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 氧化应激是衰老的一个关键因素.
- 益生菌具有抗氧化特性,但其抗衰老机制尚未完全理解.
- 乳植物菌植物TY-Y10 (L. plantarum TY-Y10) 的抗衰老作用被研究.
研究的目的:
- 评估可活和热失活的L. plantarum TY-Y10在减轻小鼠D-银糖诱导的衰老中的有效性.
- 阐明涉及氧化应激,肠道微生物群和肝功能的潜在抗衰老机制.
- 探索肠肝轴在益生菌介导的抗衰老作用中的作用.
主要方法:
- 小鼠接受了D-银糖诱导的衰老,并接受了L. plantarum TY-Y10或甲酸盐的治疗.
- 分析包括氧化应激标志物 (MDA,谷氨,SOD,CAT,GPx),肝脏健康指标和肠道微生物群组成.
- 评估了Nrf2和相关抗氧化酶的基因表达.
主要成果:
- L. plantarum TY-Y10显著降低了氧化应激标志物和炎症.
- 抗氧化酶水平和Nrf2通路激活在肝脏中得到增强.
- 肠道微生物群的组成得到了改善,产生短链脂肪酸 (SCFA) 的细菌和SCFA水平增加.
- 益生菌治疗减轻了肝脏损伤.
结论:
- 活力和热失活的L. plantarum TY-Y10都通过减少小鼠模型中的氧化应激来显示显著的抗衰老作用.
- 益生菌通过调节肠道微生物群和通过肠肝轴激活肝脏抗氧化途径来发挥作用.
- L. plantarum TY-Y10代表了与年龄相关的氧化应激和相关疾病的有前途的治疗剂.
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