分析益生菌对肠-前列腺轴的有益影响,使用前列腺共培模式
Sara Ferrari1, Rebecca Galla1,2, Simone Mulè1
1Laboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, Italy.
Foods (Basel, Switzerland)
|November 27, 2024
概括
这项研究表明,口服益生菌,特别是Bifidobacterium longum和Bifidobacterium psychaerophilum,通过调节关键疾病机制,可以显著改善肠道健康并减轻良性前列腺增生 (BPH).
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 肠道微生物对前列腺健康的影响是一个新兴的研究领域.
- 良性前列腺增生症 (BPH) 是老年男性常见的疾病,需要新的治疗策略.
研究的目的:
- 研究一种含有Bifidobacterium longum和Bifidobacterium psychaerophilum的新型口服益生菌补充剂用于BPH治疗的治疗潜力.
- 评估这些益生菌对肠道健康的影响及其随后对前列腺组织的影响.
主要方法:
- 利用3D肠道屏障模型来模拟口服益生菌的摄入,并评估它们对肠道健康的影响.
- 在BPH模拟条件下使用共培养前列腺模型来分析益生菌媒介的生物后果.
主要成果:
- 益生菌显著降低了反应性氧化物种 (6x) 和炎症标志物,如互白蛋白-6和10 (5x).
- 观察到肠道经过后丸激素和血清激素水平 (95%) 的大幅增加.
- 证明BPH介导体如雄激素和二激素的生理水平几乎恢复,并且减少了前列腺细胞的增殖.
结论:
- 肠道微生物组直接影响前列腺健康,有潜在的益生菌疗法.
- 当Bifidobacterium longum和Bifidobacterium psychaerophilum结合在一起时,通过调节关键的致病途径来缓解BPH,显示出有希望的结果.
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