人类补充AM3,精子胺和黑斯匹里丁可以增强免疫功能,降低生物年龄,改善氧化-炎症状态:一项随机对照试验
Judith Félix1,2, Estefanía Díaz-Del Cerro1,2, Adriana Baca1
1Department of Genetics, Physiology and Microbiology (Animal Physiology Unit), Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain.
Antioxidants (Basel, Switzerland)
|November 27, 2024
概括
这项研究发现,AM3,精素和素的混合物可将生物年龄 (BA) 降低11年. 该补充剂还改善了免疫功能,减少了氧化-炎症标志物,支持健康的衰老.
科学领域:
- 老年学和免疫学 在老年学和免疫学.
- 营养科学 营养科学
- 生物化学 生化学
背景情况:
- 众所周知,AM3,精氨酸和氨酸具有抗氧化和抗炎性质.
- 这些化合物对生物年龄 (BA) 的影响仍然在很大程度上未被探索.
- 了解它们对衰老和免疫力的影响,对于制定健康的衰老策略至关重要.
研究的目的:
- 为了研究2个月的补充剂混合物 (AM3,精子胺,hesperidin) 对生物年龄 (BA) 的影响.
- 评估补充剂对免疫功能,氧化还原状态和炎症的影响.
- 为了确定混合物是否可以使BA复苏并促进健康的衰老.
主要方法:
- 一个随机对照试验,涉及41名30-63岁的参与者.
- 补充组每天接受AM3 (150毫克),精子素 (0.6毫克) 和hespéridine (50毫克) 的混合物两个月.
- 免疫功能,氧化还原状态,细胞因子水平和BA (使用免疫时钟模型) 在治疗前后被测量.
主要成果:
- 补充剂混合物显著改善了通过免疫钟测量的免疫功能.
- 服用补充剂的参与者显示,生物年龄平均减少了11年.
- 混合物有效地降低了参与者的氧化-炎症状态.
结论:
- 经过测试的补充剂混合物是生物年龄复苏的有希望的策略.
- 这种干预可以通过改善免疫力和减少炎症来实现健康的衰老.
- 对这些化合物的抗衰老潜力的进一步研究是有必要的.
相关概念视频
01:26Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
01:37Mitochondria
11.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.1K
01:22iPS Cell Differentiation
2.6K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.6K