氧化应激和表观遗传学之间的交叉:揭示人类不孕症中的新生物标志物
Sulagna Dutta1,2, Pallav Sengupta3, Filomena Mottola4
1Basic Medical Sciences Department, College of Medicine, Ajman University, Ajman 346, United Arab Emirates.
Cells
|November 27, 2024
概括
表观遗传变化,包括microRNAs (miRNAs),通过影响精子和卵子发育,影响男性和女性的生育能力. 氧化应激是改变这些表观遗传调节者的关键因素,为不孕不育提供了新的诊断和管理目标.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 表观遗传变化,包括DNA甲基化和非编码RNA (ncRNA) 活动,越来越多地与人类不孕症有关.
- 特定的microRNAs (miRNAs) 和SIRT1等因素在调节男性和女性的生殖过程中起着至关重要的作用,包括细胞亡,精子生产,卵巢生成和卵巢储备.
研究的目的:
- 审查和讨论与男性和女性生育相关的主要表观遗传生物标志物.
- 探索氧化失衡在改变关键表观遗传调节者的作用.
- 提供对不育夫妇的诊断和管理的未来观点.
主要方法:
- 对人类生殖中的表观遗传机制 (DNA甲基化,基因质修饰,ncRNAs) 的文献综述.
- 鉴定特定的miRNA和与不孕症有关的基因.
- 对氧化压力与生育能力表观遗传失调之间的联系的分析.
主要成果:
- 一些miRNAs (例如,miR-34家族,男性的miR-449;女性的miR-100-5p家族) 和SIRT1被确定为生育的关键.
- 由氧化应激等因素驱动的表观遗传失调,可以导致缺陷的精子生成,卵细胞成熟失败和胚胎发育的改变.
- 由环境和生活方式因素引起的氧化应激是关键表观遗传调节器变化的主要贡献者.
结论:
- 与氧化失衡相关的表观遗传生物标志物对于理解和潜在地诊断不孕症至关重要.
- 针对受氧化压力影响的表观遗传通路,可能为不孕夫妇提供新的治疗策略.
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