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Updated: May 5, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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失去Dnah5降低了Dync1h1的表达,导致皮质发育障碍和先天性水脑

Koichiro Sakamoto1, Masakazu Miyajima1,2, Madoka Nakajima1

  • 1Department of Neurosurgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Cells
|November 27, 2024
PubMed
概括

在Dnah5-knockout小鼠中,dynein缺乏导致先天性水头症,通过损害状功能和皮质发育,导致快速腹腔扩大.

关键词:
在 Dnah5 5 里面.细胞质体中的dynein.移动的乳毛是有机的神经发生神经发生.主要的乳毛是主要的乳毛.

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