细胞外pH在瘤微环境中的新兴作用作为癌症免疫疗法的治疗标

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Updated: Jun 6, 2025

Establishment of an Extracellular Acidic pH Culture System

Establishment of an Extracellular Acidic pH Culture System

Published on: November 19, 2017

Md Ataur Rahman¹, Mahesh Kumar Yadab¹, Meser M Ali¹

¹Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.

|November 27, 2024

概括

瘤酸度 (TME) 通过使抗瘤免疫细胞失活并促进免疫抑制,阻碍免疫疗法. 针对乳酸代谢和pH值提供了一个有希望的策略,以恢复免疫功能和改善癌症免疫治疗结果.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
生物化学生物化学

背景情况:

瘤微环境 (TME) 中的细胞外酸性是免疫疗法疗效的关键挑战.
酸性TME会损害抗瘤免疫细胞 (T细胞,NK细胞) 的功能,并促进免疫抑制细胞 (MDSC,Tregs).
瘤的酸性增强Treg衍生的外体释放,放大免疫抑制,并创建一个"保护盾牌"对抗癌症免疫力.

研究的目的:

审查细胞外pH (pHe) 调节在TME中的作用.
探索瘤酸度如何影响免疫反应和免疫治疗结果.
讨论针对pHe的治疗策略,以增强癌症免疫疗法.

主要方法:

对TME pH,免疫细胞功能和免疫疗法研究的文献综述.
对导致细胞外酸化的分子机制的分析.
检查针对乳酸代谢和pH调节的治疗方法.

主要成果:

酸性TME导致免疫细胞无能化和免疫抑制细胞的招募.
瘤酸性促进Tregs的外体细胞释放,加剧免疫抑制.
针对乳酸代谢和pH值提供了一种可行的策略,以恢复抗瘤免疫力.

结论:

调节TME pHe是克服免疫疗法耐药性的有希望的策略.
识别调节pHe的新型基因和分子通路提供了新的治疗点.
进一步的临床研究对于验证pHe向治疗在癌症患者中的有效性和安全性至关重要.

关键词:

在T细胞,T细胞.酸性TME的使用情况细胞外的pH值免疫疗法耐药性免疫疗法耐药性乳酸代谢乳酸代谢瘤微环境 (TME) 是指瘤的微环境.

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