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减肥手术后的长期癌症结果:手术程序的比较分析
Jaewhan Kim1, Kenechukwu C Ben-Umeh2, Joshua Kelley1
1Department of Physical Therapy, University of Utah, Salt Lake City, UT 84108, USA.
Cancers
|November 27, 2024
概括
代谢和减肥手术 (MBS) 对癌症风险的影响因手术而异. 可调节的胃带 (AGB) 和十二指肠开关 (BPD-DS) 显示出比Roux-en-Y胃绕道 (RYGB) 更高的癌症风险,而袖子胃切除术 (SG) 没有显著差异.
科学领域:
- 腹腔外科手术的结果
- 癌症流行病学癌症流行病学
- 手术瘤学手术瘤学
背景情况:
- 代谢和减肥手术 (MBS) 被认为可以降低癌症风险.
- 然而,不同MBS手术对癌症发病率的具体影响需要进一步研究.
研究的目的:
- 调查四种不同的MBS手术与随后的癌症发病率之间的关联.
- 为了比较Roux-en-Y胃绕道 (RYGB),可调节的胃带 (AGB),袖子胃切除术 (SG) 和十二指肠开关 (BPD-DS) 的癌症风险.
主要方法:
- 利用了来自减肥手术和全州癌症注册 (1979-2018) 的链接数据.
- 包括27,092名成年患者 (体重指数≥30公斤/米2).
- 使用Cox比例危险回归来分析MBS手术类型和癌症发病率.
主要成果:
- 在75%的患者中,Roux-en-Y胃旁路术 (RYGB) 进行.
- 与RYGB相比,可调节的胃带 (AGB) (HR=1.26,p=0.03) 和十二指肠开关 (BPD-DS) (HR=1.91,p<0.01) 与明显更高的癌症风险有关.
- 袖子胃切除术 (SG) 在癌症风险上没有显著差异 (HR=1.17,p=0.33).
结论:
- 可调节的胃带 (AGB) 和十二指肠开关 (BPD-DS) 可能与Roux-en-Y胃绕道 (RYGB) 相比增加癌症风险有关.
- 需要进一步进行大规模研究,以阐明各种MBS类型的长期癌症风险和潜在机制.
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