在延迟开始治疗后,恶性腹半质瘤的结果发生了悖论性的改善
Ashwin Kulshrestha1,2,3, Emanuela Taioli2,3,4, Andrea Wolf3
1Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cancers
|November 27, 2024
概括
恶性多叶层层层瘤 (MPM) 延迟开始治疗与更好的生存率有关,与其他癌症不同. 这表明,要优先考虑综合护理而不是快速治疗,以改善MPM患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 流行病学 流行病学
背景情况:
- 治疗开始的时间 (TTI) 是众所周知的许多癌症的生存预测因素,但它在恶性多叶膜间皮瘤 (MPM) 中的作用仍未得到检查.
- 了解影响TTI的因素及其对生存的影响对于优化MPM患者管理至关重要.
研究的目的:
- 为了调查与恶性多叶膜间皮瘤 (MPM) 开始治疗的时间 (TTI) 相关的因素.
- 确定TTI和MPM患者的整体存活率之间的关联.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库用于美国的MPM患者数据.
- 定义的TTI是从诊断到第一次治疗的几天;延迟的TTI超过了中位数.
- 采用基平方和t测试进行群组比较,以及Kaplan-Meier/Cox模型进行生存分析.
主要成果:
- 在4879名MPM患者中,中位TTI为39天.
- 延迟的TTI与改善的中位生存率有关 (13个月与早期TTI的10个月相比).
- 延迟TTI在上皮质组织学,组合疗法和最近的诊断中更为常见 (p < 0.0001);在同变量调整后,它仍然与更好的生存率有关 (HR 0.79).
结论:
- 与其他癌症相反,MPM中延迟的TTI与改善的整体存活率相关.
- 延迟可能是由于彻底的分期和前往专门中心的旅行造成的,这凸显了综合护理的价值.
- 优先考虑个性化,多学科的护理,而不是迅速启动治疗,可能会优化MPM患者的治疗结果.
相关概念视频
01:30Pleural Disorders: Types and Brief Description
183
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
183
01:28Pleural Effusion II: Symptoms and Management
154
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
154
01:27Pneumothorax-II
120
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
120