研究与母乳养和预防肥胖有关的丁基因变异和甲基化状态
Ayse Kilic1, Sacide Pehlivan2, Muhammet Ali Varkal1
1Division of General Pediatrics, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Türkiye.
Children (Basel, Switzerland)
|November 27, 2024
概括
哺乳期和特定基因变异 (LEP,LEPR) 在儿童的甲基化或等位基因频率上没有显著差异. 母亲的支持和身体活动影响了LEP基因甲基化,但需要进一步的研究.
科学领域:
- 遗传学和表观遗传学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 哺乳对婴儿发育至关重要,可能会影响基因表达和表观遗传修饰.
- 瘦素 (LEP) 和瘦素受体 (LEPR) 基因在新陈代谢和食欲调节中发挥作用.
- 表观遗传变化,如DNA甲基化,可以受到饮食等环境因素的影响.
研究的目的:
- 研究母乳养和非母乳养儿童之间的LEP和LEPR基因变异和LEP基因甲基化差异.
- 探索这些遗传和表观遗传因素与母乳养状况以及BMI和腹感等相关因素的关联.
主要方法:
- 对100名2-5岁儿童进行横截面研究,将纯母乳养的婴儿与非纯母乳养的对照进行比较.
- 对LEP 2548G/A和LEPR 668 A/G基因变异的分析以及LEP基因CpG位点 (-31和-51) 的甲基化.
- 统计分析以比较基因型/异位基因频率和甲基化百分比在不同组和不同因素之间.
主要成果:
- 在纯母乳养和非纯母乳养儿童之间的LEP/LEPR基因变异或LEP甲基化中没有发现显著差异.
- 在基因变异/甲基化和母乳养时间,BMI,家庭肥胖或腹之间没有观察到显著的关联.
- 母亲的支持和体育活动与LEP-51nt甲基化增加有关,独立于BMI,年龄或腹感.
结论:
- 仅母乳养状态并没有显著改变LEP/LEPR基因变异或甲基化模式.
- 母亲的支持和身体活动成为LEP基因甲基化的潜在调节者.
- 建议进行进一步的研究来证实这些发现,并阐明遗传学,表观遗传学和早期生命营养之间的复杂相互作用.
相关概念视频
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Genomic Imprinting and Inheritance
33.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
33.3K
Obesity
379
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
379
Non-LTR Retrotransposons
11.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K
Human Genetics
535
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
535
Cell Specific Gene Expression
13.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.5K


