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在BALB/c小鼠中,UHT牛奶补充剂影响细胞和肠-大脑轴的功能

Felipe S Lemos¹, Caio A Prins², Ana M B Martinez²

¹Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-360, Brazil.

|November 27, 2024

概括

在小鼠中,牛奶消费改变了肠-大脑轴的功能,导致神经炎症和突触功能障碍. 这导致非典型行为增加,包括低社交性和刻板印象.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

牛奶是早期发育过程中常见的饮食成分.
它与过敏反应和免疫系统激活有关.
人们越来越认识到肠-大脑轴在行为中的作用.

研究的目的:

为了研究牛奶对BALB/c小鼠肠-大脑轴的影响.
为了确定牛奶消费是否影响行为模式.
探索牛奶作为触发细胞和行为变化的潜力.

主要方法:

雄性BALB/c小鼠被分为牛奶和对照 (水) 组.
小鼠每天三次接受UHT加工牛奶或水,持续一周.
进行了组织学,免疫学和行为分析.

主要成果:

牛奶摄入扰乱了肠道组织学,影响了增殖和血细胞.
肝脏表现出促炎症反应,氧化应激和改变的葡萄糖原.
小鼠表现出血小粒细胞和T细胞的增加,神经炎症 (微质激活),以及小脑氧化合成酶2的表达.
行为变化包括社交能力低,兴趣受限和刻板印象.
突触完整性受到损害,突触后细胞减少 (Shank-3+,Drebrin+).

结论:

牛奶消费对小鼠的肠-大脑轴产生了负面影响.
非典型的行为与突触功能障碍,神经炎症和氧化应激有关.
这些发现凸显了牛奶对敏感个体的潜在风险.

关键词:

行为模式行为模式牛奶是牛奶,牛奶就是牛奶.肠肝轴肠肝轴肠肝轴肠道炎症是一种肠道炎症.神经炎症是一种神经炎症.系统性炎症系统性炎症

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