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氧醇抑制DNA从颗粒细胞释放到细胞外空间后刺激与Phorbol米里斯酸盐刺激后的DNA

Yuichi Watanabe1, Takashi Obama1, Tomohiko Makiyama1

  • 1Division of Biological Chemistry, Department of Pharmaceutical Sciences, Showa University Graduate School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Biomedicines
|November 27, 2024
PubMed
概括

氧化胆固醇代谢物,称为氧醇,被发现可以抑制由博酸 (PMA) 刺激的粒细胞的DNA释放. 7-基托胆固醇表现出最显著的抑制作用,而不会引起细胞毒性.

关键词:
在 HL-60 的情况下,它是 HL-60 的.甲基-β-循环德克斯特林.中性粒细胞细胞外陷氧化胆固醇是一种氧化醇.

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