热应激通过调节海南黑山羊的自来影响植入过程中的子宫内膜功能
Xiaoping Li1, Yanyu Sun1, Yi Min1
1School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
Animals : an open access journal from MDPI
|November 27, 2024
概括
热应激通过影响子宫内膜,对山羊的繁殖产生负面影响. 自起着保护作用,调节它可以减轻对胚胎植入的热应激效应.
科学领域:
- 动物繁殖 动物繁殖
- 细胞生物学 细胞生物学
- 环境压力生理学生理学
背景情况:
- 热应激 (HS) 对家禽的健康和生产力产生不利影响,特别是减少胚胎植入率.
- 海南黑山羊在周植入期HS对子宫内膜的特定影响尚不清楚.
- 子宫内膜功能对于成功的胚胎植入和怀孕维持至关重要.
研究的目的:
- 调查热应激对海南黑山羊子宫内膜功能的影响.
- 探索自在调解热应激对子宫内膜受容性的影响中的作用.
- 评估调节自的潜力,以抵消热应激引起的生殖障碍.
主要方法:
- 在体外实验中使用来自对照和热应激海南黑山羊的子宫组织进行实验.
- 一个2x2的因子设计,涉及温度条件 (37°C对42°C) 和自调节器 (氨酸和拉巴胺氨酸).
- 对自活动,子宫内膜上皮细胞 (EEC) 感受性标记物和紧接蛋白TJP1表达的分析.
主要成果:
- 热应激最初被抑制,然后在长时间暴露时增强了自活动.
- 自的药理调节改变了EEC受体标志物,ATG7过度表达部分逆转了HS诱导的下调.
- 自激活导致TJP1降解,而用氨酸抑制在热应激下增加了TJP1积累.
结论:
- 在海南黑山羊的热应激条件下,自在维持子宫内膜功能和受容性方面发挥着保护作用.
- 调节自活动是减轻山羊热应激对生殖的不利影响的潜在策略.
- 了解自的作用对于在具有挑战性的热环境中提高牲畜生殖效率至关重要.
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