通过益生菌和益生菌补充剂调节狗肠道微生物群:使用新型结肠发酵模型进行长期体外研究
Alessandro Gramenzi1, Luana Clerico2, Benedetta Belà1
1Department of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.
Animals : an open access journal from MDPI
|November 27, 2024
概括
食补充剂可以改善狗的肠道健康. 结合益生菌和益生菌显著改变了肠道微生物群,增强了有益的细菌和促进发酵.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 动物营养 动物营养
背景情况:
- 肠道微生物群对于狗的健康至关重要,影响免疫力,消化和病原体防御.
- 饮食干预可以调节肠道微生物群.
研究的目的:
- 为了评估一种益生菌 (Microbiotal),一种益生菌 (Lactobacillus reuteri) 和一种组合对狗肠道微生物组合的影响.
- 通过体外模型评估狗结肠的光线和粘膜环境中的微生物变化.
主要方法:
- 利用SCIMETM平台模拟狗胃肠道进行体外结肠发酵.
- 采用16S rRNA测序来分析微生物社区结构和多样性.
- 应用LEfSe和treeclimbR用于微生物转移的分类学识别.
主要成果:
- 所有测试的补充剂都显著调节了关键的微生物群体,包括Limosilactobacillus,Bifidobacterium,Prevotella和Faecalibacterium的丰富.
- 同时服用益生菌和益生菌对增强糖溶性发酵和丁酸盐生产显得特别有前途.
- 在α和β多样性指数中都观察到显著的变化.
结论:
- 结合益生菌和益生菌补充剂显示了促进狗肠道健康和微生物多样性的巨大潜力.
- 这些发现为进一步研究狗肠道微生物群的代谢功能提供了基础.
- 试验室结肠发酵模型在研究食补充剂对狗肠道微生物生态的影响方面被证明是有效的.
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