校正:吉里等人. 改善蛋白质-连接体相互作用建模与冷-EM数据,模板和深度学习在2021年连接体模型挑战. 生物分子 2023,13 ,132 这些是生物分子
1Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.
Biomolecules
|November 27, 2024
概括
这项研究发现了原始出版物中的错误,需要对报告结果进行修正. 进一步的研究将澄清准确的科学结论.
科学领域:
- 对科学文献进行校正.
- 研究中的出版诚信.
背景情况:
- 在之前的出版物中发现了一个错误.
- 这需要进行正式的校正,以确保科学准确性.
研究的目的:
- 提醒科学界在先前的出版物中出现错误.
- 通过纠正记录,为未来的研究提供基础.
主要方法:
- 识别原始手稿中的特定错误.
- 发出正式的纠正通知.
主要成果:
- 原始出版物中包含一个影响报告结果的错误.
- 错误的具体性质在修正中详细说明.
结论:
- 由于发现的错误,原刊的调查结果可能是不准确的.
- 纠正的信息将对后续在该领域的研究至关重要.
相关概念视频
02:40Ligand Binding Sites
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Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
02:40Ligand Binding Sites
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
01:28Cryo-electron Microscopy
Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...