长期体力活动缓解了COVID-19大流行期间老年人的炎症进展
Carlos André Freitas Dos Santos1, Ariane Nardy2, Renato Jimenez Gomes2
1Postgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil.
International journal of environmental research and public health
|November 27, 2024
概括
COVID-19 疫情影响了老年人的身体表现和炎症. 炼和恢复炼在老年男性和女性中引起了明显的变化,突出了持续体育活动的重要性.
科学领域:
- 老年学和运动科学
- 免疫学和衰老研究研究
背景情况:
- 研究了COVID-19流行病对老年人的炎症和身体表现的影响.
- 检查了锁定前,锁定期间和恢复运动训练后的变化.
研究的目的:
- 评估大流行引起的炼和随后的运动恢复对老年人身体能力和炎症标志物的影响.
- 在应对这些变化时识别性别特异性差异.
主要方法:
- 在三个时间点评估了25名老年人 (18名女性,7名男性):大流行前,12个月后的封锁,以及10个月后的运动恢复.
- 评估身体表现 (步行速度,定时上升),肌肉力量 (握手) 和血清细胞因子水平 (IL-6,IL-8,IL-10,IL-12p70,TNF-α,IFN-γ).
主要成果:
- 年龄较大的女性在锁定后表现出改善的步行速度和定时上行,但在恢复训练后手握力降低. 年长的男性在整个过程中表现出手握力下降.
- 两组都显示出改变的细胞因子概况,包括IL-10,IL-12p70的变化,以及益炎和抗炎细胞因子的比率,因时间点和性别而异.
- 特定的细胞因子模式,如较低的IL-6和较高的TNF-α/IL-10和IFN-γ/IL-10比率,在流行后的老年女性中被发现.
结论:
- 在COVID-19大流行期间的炼和随后的炼恢复导致身体功能的明显变化以及老年男性和女性的炎症.
- 这些发现强调了不活动和运动对衰老过程和身体能力的不同影响,强调了需要量身定制的干预措施的必要性.
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