暴露与前列腺癌之间的关联:更新的系统审查和元分析
Giorgio Firmani1, Manuela Chiavarini1,2, Jacopo Dolcini1
1Department of Biomedical Sciences and Public Health, Section of Hygiene, Preventive Medicine and Public Health, Polytechnic University of the Marche Region, 60131 Ancona, Italy.
International journal of environmental research and public health
|November 27, 2024
概括
这项研究调查了暴露和前列腺癌 (PCa) 风险. 虽然总体结果并不显著,但欧洲研究表明存在潜在联系,高暴露与具有攻击性的PCa类型相关.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 毒理学 毒理学 毒理学
背景情况:
- 前列腺癌 (PCa) 是男性患有复杂原因的流行恶性瘤.
- (Cd) 是一种有毒的重金属,并被IARC分类为致癌物,对健康构成风险.
- 以前的研究表明,暴露与前列腺癌之间存在联系.
研究的目的:
- 进行系统审查和元分析,更新暴露与前列腺癌之间的关联.
- 将最近的研究纳入其中,以完善对这种关系的理解.
主要方法:
- 在PubMed,Web of Science和Scopus数据库中进行全面的文献搜索,直到2024年5月.
- 包括八篇新文章,结合以前的数据进行元分析.
- 用于计算效果大小的随机效应模型;评估异质性和出版偏差.
主要成果:
- 与暴露相关的PCa的整体效应大小为1.11 (95% CI 0.85-1.45),具有很高的异质性.
- 欧洲研究表明显著效果大小为1.47 (95% CI 1.00-2.17).
- 以前的分析显示,较高的暴露与更激进的PCa组织病理学有关 (OR 1.50,95% CI 1.08-2.07).
结论:
- 暴露于可能会引起有关前列腺癌风险的公共卫生问题.
- 地理差异,特别是在欧洲,需要进一步研究.
- 进一步的研究至关重要,以阐明暴露对前列腺癌的确切风险.
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