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窗户覆盖和液体活检在严重的突然感觉神经听力损失的第一线治疗中

Alexander Kilgue¹, Rayoung Kim¹, Lars-Uwe Scholtz¹

¹Department of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.

|November 27, 2024

概括

突然的感觉神经听力损失 (SSNHL) 可能是由周周淋巴 (PLF) 引起的. 早期耳 tympanoscopy和可克林-蛋白 (CTP) 测试在70%的患者中发现了PLF,导致手术窗口密封后听力显著改善.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
神经外科神经外科
听力学听力学是指听力学.

背景情况:

皮质类固醇是突然感觉神经听力损失 (SSNHL) 的标准,但周周淋巴 (PLF) 是一个被诊断不足的原因.
考林-图莫蛋白 (CTP) 检测为SSNHL中PLF提供了一种新的诊断方法.
需要根据PLF患病率重新评估SSNHL病因.

研究的目的:

在SSNHL患者中评估可克林-托莫蛋白 (CTP).
在怀疑PLF的圆形和圆形窗口密封后,比较手术前和手术后的听力值.
评估CTP的诊断价值,以确定PLF是SSNHL的原因.

主要方法:

对30名单边SSNHL患者的前性研究,听力损失≥60dB PTA.
第一线治疗包括中耳探测和圆形/形窗口密封的耳镜.
中耳洗用于CTP采样和ELISA测试;术后听力通过骨传导 (BC) 值进行评估.

主要成果:

手术前的平均BC值为97.7dB,手术后改善到69dB (20.3dB平均改善).
56%的患者 (17/30) 实现了≥10dB的听力恢复.
中耳样本中CTP检测率为70%阳性.

结论:

早期耳 tympanoscopy 结合 CTP 测试有效地识别了 SSNHL 中的 PLF.
在很大一部分SSNHL病例中,PLF是关键的致病因素.
圆形和圆形窗户的手术密封是一种有效的第一线治疗PLF相关的SSNHL.

关键词:

科林-托莫蛋白 (CTP) 是一种可克林-托莫蛋白.周周淋巴裂 (PLF) 是一种突发的感觉神经听力损失 (SSNHL)tympanoscopy 时间镜检查

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