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孕激素在COVID-19中的作用及其与潜在炎症反应的关联

Eleni Polyzou^1,2, Georgios Schinas¹, Panagiotis Bountouris³

¹School of Medicine, University of Patras, 26504 Rio, Greece.

International journal of molecular sciences

|November 27, 2024

概括

益生素 (PRL) 不是预测COVID-19严重程度的可靠生物标志物. 这项研究发现,在COVID-19患者的PRL水平和临床结果之间没有显著的关联,这表明其他标记物更可靠.

科学领域:

免疫学免疫学免疫学
内分泌学在内分泌学.
传染性疾病传染性疾病

背景情况:

由于COVID-19的流行,我们需要可靠的生物标志物来预测疾病的严重程度.
具有免疫调节功能的激素益生素 (PRL) 已成为一种潜在的生物标志物.
了解PRL在COVID-19病变发生中的作用对于临床管理至关重要.

研究的目的:

评估益生素 (PRL) 作为预测COVID-19疾病严重程度的生物标志物.
调查基线PRL水平,细胞因子概况和COVID-19患者的临床结果之间的关联.

主要方法:

研究了142名中度至重度COVID-19患者 (WHO-CPS 5或6) 的前性队列.
基线血清益生素 (PRL) 水平通过电化学发光免疫测试进行测量.
血清细胞因子 (IL-1β,IL-6,IL-8,IL-10,IL-12p70,TNF-α) 使用流细胞计量进行了量化.

主要成果:

在女性患者中观察到较高的PRL水平 (12.95 ng/mL vs. 9.40 ng/mL,p < 0.001).
PRL水平与严重性指数 (CCI,SOFA分数) 或炎症标志物没有相关性.
在PRL,细胞因子水平和临床结果 (死亡率,侵入性机械通风) 之间没有发现显著的关联.

结论:

益生菌 (PRL) 对COVID-19疾病严重程度的预后可靠性有限.
已建立的预测标记似乎比PRL更可靠,用于评估COVID-19的严重程度.
在COVID-19免疫反应中PRL的确切作用需要进一步调查.

关键词:

在 COVID-19 疫情中,生物标志物生物标志物队列研究是指队列研究.细胞因子细胞因子疾病的严重程度.免疫调节免疫调节免疫调节炎症标志物的炎症标志物益生菌蛋白是一种益生菌素.性别差异的性别差异.病毒感染病毒感染

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