刺信号通路及其在塑造肠表皮结构中的作用
Adrianna Konopka1, Kamil Gawin2, Marcin Barszcz1
1Laboratory of Analysis of Gastrointestinal Tract Protective Barrier, Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.
International journal of molecular sciences
|November 27, 2024
概括
刺 (Hh) 信号通路对于肠道发育和肠道平衡至关重要. 饮食和微生物群影响Hh通路活性,影响肠道粘膜结构和完整性.
科学领域:
- 胃肠病学 胃肠病学
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 刺 (Hh) 信号通路对于肠道发育,肠道平衡和调节关键细胞过程至关重要.
- 关键配体,印度刺 (Ihh) 和Sonic刺 (Shh),通过作用于介质细胞来调解Hh信号.
- Hh通路与Wnt信号密切相关,并充当肠道细胞增殖的负反调节器.
研究的目的:
- 审查Hh信号通路在塑造肠道粘膜中的关键作用.
- 总结当前关于饮食成分如何影响Hh通路活性的研究.
- 要突出Hh通路对肠道平衡和粘膜架构的影响.
主要方法:
- 对调查肠道发育和功能中的Hh信号通路的研究进行文献综述.
- 对饮食成分和肠道微生物群对Hh通路基因和蛋白质表达的影响的研究分析.
- 与干细胞更新,细胞循环和粘膜完整性的Hh通路调节相关的发现的综合.
主要成果:
- Hh信号调节干细胞的更新,状密码轴的形成,细胞分化,细胞循环,细胞亡,肠道内化和脂质代谢.
- 脂肪,维生素A,血,柏柏林和卵子转移素等食因素可以改变Hh通路基因/蛋白质表达和粘膜架构.
- 肠道微生物群影响Hh信号和肠道屏障完整性.
结论:
- Hh信号通路是肠道发育和平衡的关键调节器.
- 饮食成分和肠道微生物群是Hh通路活性的显著调节者,影响肠道健康.
- 对饮食调节Hh通路的进一步研究有望为肠道健康的治疗策略提供潜力.
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