在患有多发性硬化症的女性中改变了类固醇
Radmila Kancheva1, Martin Hill1, Marta Velíková1
1Institute of Endocrinology, 11000 Prague, Czech Republic.
International journal of molecular sciences
|November 27, 2024
概括
多发性硬化症患者表现出改变的类固醇代谢,具有较高的合类固醇比率和失调的皮质醇和雄激素通路,影响神经炎症和疾病过程. 这项研究揭示了与对照组相比,女性多发性硬化症患者的关键类固醇差异.
科学领域:
- 内分泌学和新陈代谢学
- 神经免疫学 神经免疫学
- 类固醇组合物 (steroidomics) 是一种
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病,主要影响年轻女性.
- 类固醇会影响MS的发病和进展,但MS中缺乏全面的类固醇组分析.
- 了解类固醇组概况对于阐明多发性硬化病原和潜在的治疗点至关重要.
研究的目的:
- 对女性多发性硬化症患者进行全面的类固醇组分析,与年龄相匹配的对照进行比较.
- 研究类固醇代谢途径的变化,包括皮质醇,雄激素和神经活性类固醇.
- 探索类固醇特征与MS中神经保护和神经炎症通路的平衡之间的关系.
主要方法:
- 使用气体染色学并联质谱法 (GC-MS/MS) 的类固醇组分析.
- 免疫试验用于雌醇量化.
- 25名女性多发性硬化患者和15名女性年龄匹配对照之间的类固醇配置文件的比较.
主要成果:
- 患者表现出一种趋势,即合类固醇与未合类固醇的比率更高.
- 皮质醇代谢发生变化,孕醇转化减少,11-脱氧类固醇转化为11β-氧类固醇转化受损,尽管由于HPAA过度激活而导致皮质醇/皮质素水平升高.
- 观察到脱水氨 (DHEA) 转化为雄激素和雌激素的减少,较低的全孕,以及3β-基类固醇与3α-基类固醇的比率增加.
结论:
- 女性多发性硬化症患者表现出显著的类固醇基因变化,包括失调的雄激素和皮质醇合成和代谢.
- 观察到的类固醇特征的变化可能会导致神经炎症和神经活性类固醇调节剂在MS中的失衡.
- 这些发现突显了类固醇组分析在了解多发性硬化症病理生理学和确定新型治疗策略方面的潜力.
相关概念视频
02:07Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K
01:28Menopause
138
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
138
01:19Mesenchymal Stem Cells
4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
01:24Disorders of the Female Reproductive System
328
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
328