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在患有清细胞细胞癌的患者中,确定逆向蛋白作为一种新的预后标志物

Ivanka Urlić¹, Violeta Šoljić^2,3, Martina Vukoja²

¹Department of Oncology and Radiotherapy, University Hospital of Split, 21000 Split, Croatia.

International journal of molecular sciences

|November 27, 2024

概括

在清细胞脏细胞癌 (ccRCC) 瘤中,逆向蛋白的表达较低. 较低的反素水平与较差的存活率和转移率的增加相关,这表明其作为预后因素的潜力.

科学领域:

在瘤学瘤学.
精准医学是一门精准的医学.
细胞癌研究细胞癌研究

背景情况:

清细胞细胞癌 (ccRCC) 需要新的预后因素和治疗目标.
精准医学方法正在推进ccRCC的治疗和预后.

研究的目的:

研究cccRCC中作为预后因子和治疗点的反素表达.
分析inversin,其相互作用组伙伴和ccRCC患者的结果之间的关系.

主要方法:

免疫组织化学和rtPCR用于评估ccRCC和正常组织中的反向蛋白表达.
分析了来自癌症基因组图谱 (TCGA) -KIRC队列的公开数据.
在基因表达,生存数据,瘤特征和免疫标记物之间进行了相关性分析.

主要成果:

与正常脏组织相比,ccRCC瘤中的逆向蛋白表达显著较低.
较低的逆向因子 (INVS) 表达与减少的整体和疾病特异性存活率以及较短的无进展间隔相关.
反向因子互动组伙伴的表达 (例如,ANKS6,NPHP3,DVL1,DVL3) 也显示出与生存结果的显著关联.
基因表达水平与瘤分化,转移,白细胞透和免疫检查点基因有关.

结论:

逆向蛋白和特定的相互作用组伙伴是ccRCC的潜在预后因素.
这些因素参与调节瘤微环境的炎症透和转移潜力.
对逆向素作用的进一步研究可能会为ccRCC带来新的治疗策略.

关键词:

清晰细胞脏细胞癌.互动的作用组.在反向的反向中.预后预后预后目标目标目标目标目标目标目标.

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