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相关概念视频

Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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随着衰老的内皮功能障碍:性是否重要?

Jakub Jozue Wojtacha1, Barbara Morawin1, Edyta Wawrzyniak-Gramacka1

  • 1Department of Applied and Clinical Physiology, University of Zielona Gora, 28 Zyty Str., 65-417 Zielona Gora, Poland.

International journal of molecular sciences
|November 27, 2024
PubMed
概括

这项研究揭示了老年人中氧化应激和炎症标志物的性别特异性差异,影响血管疾病风险. 了解这些特定于性别的氧-炎症反应对于预测和预防老年人群中心血管事件至关重要.

关键词:
3 - - 尼铁氨酸的使用.血细胞计数是指血液中的细胞数量.内皮前代细胞是内皮前代细胞.氧化氧化的使用方法年龄较大的成年人.系统性炎症指数

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科学领域:

  • 老年学和心血管研究研究.
  • 氧化应激和炎症的生物化学
  • 基于性别的健康差异

背景情况:

  • 老年人的内皮功能障碍与过度反应性氧和物种 (RONS) 的氧化应激和炎症有关.
  • 现有的研究往往忽略了这些生理过程中的性别特异性变异,这可能会限制有效的血管疾病预测和预防策略.
  • 了解RONS,炎症和内皮健康的相互作用对于解决老年人群中心血管风险至关重要.

研究的目的:

  • 研究血清氧-炎症标志物对预测和预防血管疾病的有用性,特别关注性别差异.
  • 阐明老年妇女和男性中氧化应激和炎症的独特机制.
  • 确定可靠的性别特异性生物标志物,以评估内皮功能障碍和心血管风险.

主要方法:

  • 对145名女性和50名男性 (平均年龄为72.2±7.8岁) 的血清样本进行过氧化 (H2O2),氧化 (NO) 和3-甲酸铁 (3-NitroT) 水平的分析.
  • 评估NO/3-NitroT比率与内皮功能障碍之间的性别相关性.
  • 评估炎症特异性变量 (中性粒细胞与淋巴细胞的比率,全身免疫炎症指数,中性粒细胞与高血糖的比率,CRP与高血糖的比率) 和它们的诊断效用.

主要成果:

  • 老年女性的H2O2和NO产量增加,NO生物可用性降低 (3-NitroT高),表明性别特异性内皮功能障碍.
  • NO/3-NitroT关系在性别之间有显著差异 (女性: rs = 0.811;男性: rs = -0.611),突出性别作为内皮功能障碍的决定因素.
  • 女性表现出循环原生细胞增加,表明内皮细胞同时再生,炎症标志物减少,CRP-HDL比率显示出高诊断效用 (AUC = 0.980).

结论:

  • 这项研究是首次证明氧炎反应的性别特异性变化有助于老年人血管功能障碍.
  • 性别特定的生物标志物,特别是C反应蛋白与HDL的比率,可以有效地预测血管功能障碍的临床预后.
  • 这些发现强调了在评估和管理老年人心血管疾病风险时考虑性别的重要性.