急性和慢性阻力训练,急性耐力运动,以及生理学上可信的乳酸盐在体外影响骨肌肉乳糖化
Madison L Mattingly1, Derick A Anglin1, Bradley A Ruple2,3
1School of Kinesiology, Auburn University, Auburn, AL 36849, USA.
International journal of molecular sciences
|November 27, 2024
概括
抵抗运动影响骨肌肉蛋白质的乙化,而不是乳化. 慢性和急性抵抗训练减少了细胞质蛋白质的乙化,而乳化在对各种运动类型和乳酸治疗的反应中保持不变.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 生物化学 生化学
背景情况:
- 骨肌肉适应运动涉及复杂的分子变化.
- 蛋白质乳化和乙化是受代谢状态影响的翻译后修改.
- 了解运动引起的变化对于优化训练和健康结果至关重要.
研究的目的:
- 研究急性和慢性抵抗训练 (RT) 对骨肌肉蛋白质乳化和乙化的影响.
- 检查急性耐力循环对这些蛋白质修饰的影响.
- 为了确定不同酸盐度对髓管蛋白质乳化和乙化的 in vitro 影响.
主要方法:
- 人类研究涉及从巨大的横向肌肉的活检,遵循RT和循环协议.
- 在体外实验中,使用C2C12菌根管处理不同度的乳酸.
- 核和细胞质蛋白质乳酸和乙化水平的分析.
主要成果:
- 无论是急性还是慢性RT都没有显著改变蛋白质乳糖化.
- 在单次RT发作和慢性RT后,细胞质蛋白乙化显著降低.
- 急性循环不影响蛋白质乳糖化或乙化;体外乳酸治疗没有影响.
结论:
- 运动,特别是阻力训练,会诱导骨肌肉蛋白质乙化中的动态变化,但不能诱导乳糖化.
- 目前的发现表明,蛋白质乙化对运动刺激的反应比乳化更快.
- 需要进一步研究先进的乳糖组学和多样化的采样时间点,以充分阐明运动模式对蛋白质乳糖化的影响.
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