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产前暴露于内分泌干扰化学物质的人类相关混合物影响小鼠部发育

Vagelis Rinotas¹, Antonios Stamatakis², Athanasios Stergiopoulos²

¹Institute for Fundamental Biomedical Research (IFBR), Biomedical Research Center "Al. Fleming", 16672 Vari, Greece.

International journal of molecular sciences

|November 27, 2024

概括

孕期暴露于内分泌干扰化学物质 (EDC) 影响了小鼠下发育,改变了骨结构和生长. 这项研究揭示了产前EDC暴露对部发育的潜在风险.

科学领域:

发育生物学是发展生物学.
毒理学毒理学毒理学
面研究的研究.

背景情况:

下巴对于和说话至关重要,对环境因素非常敏感.
内分泌干扰化学物质 (EDC) 与发育问题有关,包括神经发育影响.
混合物N1是一种具有已知的神经发育影响的EDC混合物.

研究的目的:

为了研究产前暴露于混合物N1对雄性小鼠下生长的影响.
为了确定EDC暴露对面发育的剂量依赖性和非单调性影响.

主要方法:

怀孕的小鼠在怀孕期间暴露于不同剂量的混合物N1 (0.5×,10×,100×,500×) 或载体.
分析了成年男性后代的下,使用微型计算机断层扫描 (Micro-CT).
组织学分析 (Safranin-O染色) 评估了状细胞的发育.

主要成果:

在下标志距离和M1冠宽度观察到的非单调效应.
在500×曝光时减少了膜骨体积和增加了椎骨分离.
在所有治疗组中增加了状头骨体积.
在0.5×,10×和100×暴露组中减少了冠状细胞区域.

结论:

产前暴露于EDC混合物 (混合物N1) 显著影响小鼠下的生长和骨特征.
观察到的影响包括骨密度,尺寸和软骨发育的改变.
这项研究提供了第一个证据,将流行病学相关的EDC混合物与哺乳动物下部发育影响联系起来.

关键词:

欧洲发展中心 (EDCs)下巴下巴是一个鼠标鼠标鼠标鼠标在微型CT中使用微型CT.

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