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通过ADMET和有毒基因组学分析在中探索Per-和多基物质 (PFAS) 混合物的毒性:分子洞察力

Katarina Baralić¹, Teodora Petkovski¹, Nađa Piletić¹

¹Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.

International journal of molecular sciences

|November 27, 2024

概括

和多醇基物质 (PFAS) 混合物存在器官毒性和代谢干扰的风险. 确定了参与脂质代谢和核受体信号传递的关键基因,将PFAS与糖尿病和肥胖等疾病联系起来.

科学领域:

环境毒理学环境毒理学
计算毒理学计算毒理学
基因组学就是基因组学.

背景情况:

和多基基物质 (PFAS) 是广泛存在的环境污染物.
有关PFAS混合物的健康影响存在担忧.
了解PFAS毒性的分子机制至关重要.

研究的目的:

调查突出的PFAS混合物的健康影响和毒性机制.
为了确定与PFAS暴露相关的关键基因生物标志物.
为了全面评估,使用in silico ADMET和毒基因组学分析.

主要方法:

在使用AdmetSAR和ADMETlab.lab的基ADMET分析中.
毒基因组分析整合了比较毒基因组数据库,ToppGene,Metascape和GeneMANIA.
使用Cytoscape与CytoHubba和CytoNCA插件进行基因网络和通路分析.

主要成果:

在ADMET分析中,发现了与PFAS相关的器官特异性毒性,长期保留和代谢中断.
确定了40个共同基因,主要与通过核受体破坏脂质代谢有关.
涉及的关键途径包括核受体信号和PPAR信号,与脏/肝脏疾病,糖尿病和肥胖症有关.
通过网络分析确定了八个关键基因 (EHHADH,APOA2,MBL2,SULT2A1,FABP1,PPARA,PCK2,PLIN2).通过网络分析确定了八个关键基因 (EHHADH,APOA2,MBL2,SULT2A1,FABP1,PPARA,PCK2,PLIN2).

结论:

PFAS混合物对健康构成重大风险,包括器官毒性和代谢障碍.
脂质代谢和核受体信号的破坏是PFAS毒性的关键机制.
已识别的基因生物标志物和途径为PFAS相关疾病的发展提供了洞察力.
进一步的研究是必不可少的,以充分阐明PFAS混合物带来的健康风险.

关键词:

在PFAS中,有很多方法.基因基因基因基因 perfluoro-nonanoic 酸是一种非酸的化合物.perfluorodecanoic 酸的使用情况 perfluoroheptanesulfonic 酸的含量是什么 perfluorohexanesulfonic 酸是一种含的化合物.perfluorooctanesulfonic 酸的含量是什么 perfluorooctanoic 酸的使用情况 perfluoroundecanoic 酸是一种不常见的化学化合物 .毒性动力学毒性动力学

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