Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Conserved Binding Sites01:49

Conserved Binding Sites

4.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
4.2K
From DNA to Protein03:06

From DNA to Protein

18.0K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
18.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Can Pareto Optimality Be Evidence of Life?

Astrobiology·2026
Same author

Abiotic CO<sub>2</sub> reduction promoted by carbonate and phyllosilicate minerals on the primitive seafloor.

Nature communications·2026
Same author

Beyond α-Glucosidase and α-Amylase Inhibition: Integrated In Vitro and Multi-Scale In Silico Insights into the Antidiabetic and Antioxidant Mechanisms of <i>Oxalis corniculata</i> L. Aerial Parts.

Molecules (Basel, Switzerland)·2026
Same author

In Search of the Most Significant Potential G-Quadruplexes in SARS-CoV-2 RNA: Genomic Analysis.

Viruses·2026
Same author

Lightning-driven plasma bubbles provide prebiotic synthesis and biogeochemical cycling.

Chemical communications (Cambridge, England)·2026
Same author

Organic geochemical evidence for life in Archean rocks identified by pyrolysis-GC-MS and supervised machine learning.

Proceedings of the National Academy of Sciences of the United States of America·2025

相关实验视频

Updated: Jun 6, 2025

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.6K

计算机生成和商业图书馆的相似性分析,针对有针对性的生物相容的编码氨基酸替代.

Markus Meringer1, Gerardo M Casanola-Martin2, Bakhtiyor Rasulev2,3

  • 1German Aerospace Center (DLR), Department of Atmospheric Processors, Oberpfaffenhofen, 82234 Wessling, Germany.

International journal of molecular sciences
|November 27, 2024
PubMed
概括

我们开发了一种新的工作流程,以找到可以纳入蛋白质的非天然氨基酸. 这种方法有效地识别出与生物系统和蛋白质功能相容的候选物.

关键词:
坦尼莫托系数的使用方法氨基酸库 氨基酸库分子指纹的分子指纹.多维缩放的多维缩放.结构上的相似性.

更多相关视频

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

320
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

1.7K

相关实验视频

Last Updated: Jun 6, 2025

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.6K
Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

320
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

1.7K

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 生物系统可以将非天然的氨基酸纳入蛋白质中.
  • 有效的整合需要与蛋白质功能兼容,避免错误检查机制.
  • 以前的方法依赖于专家直觉和经验研究,这对于大规模查来说是低效的.

研究的目的:

  • 引入一种计算工作流程,用于识别用于蛋白质结合的生物类似非天然氨基酸.
  • 为了能够有效地选大型实体和计算氨基酸库.
  • 为了最大限度地减少含有非天然氨基酸的蛋白质的意外功能障碍.

主要方法:

  • 开发了一种工作流程,用于搜索氨基酸库的生物类似候选者.
  • 应用了使用Tanimoto系数的指纹相似度得分.
  • 评估图书馆,包括先前的基准分子和商业目录.

主要成果:

  • 确定了适合替代为现代蛋白质的非天然氨基酸候选者.
  • 发现了几种已经实施的氨基酸替代.
  • 为蛋白质工程提出了许多新的潜在氨基酸替代品.

结论:

  • 开发的工作流程有效地识别了潜在的非天然氨基酸替代品.
  • 这种方法扩大了蛋白质工程和设计的可能性.
  • 这些发现有助于发现用于编码蛋白质合成的新型氨基酸.