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平面扭曲分子工程用于调节使用捐赠者-接受者-捐赠者骨架的NIR-II光体的光亮度

Shengjiao Ji¹, Yuying Du¹, Jiancai Leng¹

¹International School for Optoelectronic Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.

International journal of molecular sciences

|November 27, 2024

概括

研究人员开发了扭曲的有机光体,用于增强的第二近红外 (NIR-II) 成像. 这一策略显著提高了光量子效率 (FQE) 和亮度,克服了当前NIR-II生物成像应用中的局限性.

科学领域:

有机化学有机化学
光物理学的光学物理学
生物医学成像技术生物医学成像技术

背景情况:

有机分子光体对于可见光和第一近红外 (NIR-I) 窗口中的生物成像至关重要.
在第二个近红外 (NIR-II) 窗口中的应用受到不够的光亮度的限制.
开发更明亮的NIR-II光体对于先进的生物医学成像是至关重要的.

研究的目的:

为了研究提高NIR-II光的亮度和发射的平面扭曲策略.
阐明扭曲光体中改善光物理性质背后的机制.
为生物医学应用设计和评估新型NIR-II光剂.

主要方法:

理论协议结合了热振动相关函数和时间依赖密度函数理论 (TD-DFT).
平面捐赠者-接受者-捐赠者光体的设计,带有正确位置的基侧链,用于硬质障碍.
扭曲光体的合成和光物理特征.

主要成果:

扭曲的光体表现出NIR-II发射,由于结构扭曲而出现低色变化.
形状扭曲显著增加了辐射衰变速率并抑制了非辐射衰变速率.
在扭曲结构中实现了光量子效率 (FQE) 的五倍以上的增加.
最佳光体BBTD-4在980nm发射下显示出高光亮度 (16.59M-1cm-1).

结论:

平面扭曲策略有效地提高了NIR-II光体的FQE和光亮度.
增强的光物理性能归因于增加的亚亚巴特激发能量和减少的非亚亚巴特电子合.
BBTD-4是NIR-II光成像的有希望的候选者,为开发高效的光学成像剂提供了可行的方法.

关键词:

在 NIR-II 化物中,化物含量较高.光的亮度光的亮度一个平面扭曲的战略.

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