自闭症谱系障碍中的微生物组遗传轴:益生菌的视角
Marija Mihailovich1,2, Maja Tolinački1, Svetlana Soković Bajić1
1Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 11042 Belgrade, Serbia.
International journal of molecular sciences
|November 27, 2024
概括
益生菌对自闭症谱系障碍 (ASD) 症状管理有希望,特别是胃肠道问题. 基于肠道细菌的个性化益生菌选择可能会改善ASD患者的生活质量.
科学领域:
- 神经发育障碍 神经发育障碍
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种流行的神经发育状况,具有显著的成本和有限的有效治疗方法.
- 人们越来越认识到肠道微生物群在ASD中的作用,特别是对于胃肠道 (GI) 症状,这导致人们对益生菌感兴趣.
- 现有针对ASD益生菌的临床研究由于方法的差异导致了不一致的结果.
研究的目的:
- 审查与自闭症复杂性相关的肠道细菌和代谢物的实验证据.
- 探索益生菌作为治疗自闭症谱系障碍的治疗策略的潜力.
- 为改善ASD症状和生活质量提供个人化医疗方法,用于益生菌的使用.
主要方法:
- 关于肠道细菌,代谢物和自闭症的实验证据的文献综述.
- 对自闭症谱系障碍的表型和病因复杂性和异质性的分析.
- 讨论关于治疗自闭症的益生菌现有临床试验数据.
主要成果:
- 有证据表明,特定的肠道细菌,它们的代谢物和自闭症之间存在联系.
- 目前针对自闭症的益生菌研究在设计上缺乏一致性,并产生不确定的结果.
- 自闭症的异质性需要量身定制的治疗策略.
结论:
- 针对自闭症治疗,建议采用个性化医疗方法,根据个体肠道微生物群概况选择特定的益生菌.
- 针对特定的肠道细菌及其代谢物可能会减轻自闭症谱系障碍的特定特征.
- 需要进一步的研究,以确定确定的益生菌疗效,并优化个性化治疗方案的个人与ASD.
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