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冠状病毒疾病2019年相关的血栓状微血管病变:一个单一中心的经验

Marija Malgaj Vrečko^1,2, Andreja Aleš-Rigler¹, Špela Borštnar^1,2

¹Department of Nephrology, University Medical Center Ljubljana, 1000 Ljubljana, Slovenia.

International journal of molecular sciences

|November 27, 2024

概括

冠状病毒疾病2019 (COVID-19) 可以引发血栓性微血管病变 (TMA),包括血栓性血栓细胞性紫外线和非典型的血溶性尿液性综合征. 治疗因TMA亚型和触发因素而异,在这个患者队列中没有报告死亡.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

冠状病毒疾病2019 (COVID-19) 与多系统性疾病有关.
血栓式微血管病变 (TMA) 是一种严重的并发症,在一些COVID-19患者中观察到.
了解COVID-19在TMA病原体中的作用对于有效管理至关重要.

研究的目的:

总结COVID-19相关的TMA患者的临床和人口特征.
探索SARS-CoV-2 (导致COVID-19的病毒) 作为TMA触发器的潜在作用.
讨论COVID-19相关的TMA不同亚型的治疗策略.

主要方法:

八名患有COVID-19相关TMA的患者的回顾性病例系列.
对患者人口统计,临床表现和治疗结果的分析.
对TMA的潜在COVID-19相关和无关触发因素的审查.

主要成果:

七名患者患有非典型的血液溶解-尿素性综合征 (aHUS),一名患有血栓性血栓细胞性紫外线 (TTP).
大多数患者缺乏严重的COVID-19症状;TMA表现为后病毒性.
治疗包括血交换,类固醇,卡普拉齐祖马布和补充抑制剂,的恢复有所不同,没有死亡.

结论:

COVID-19可能会在患有内皮功能障碍或补体调节障碍的易感个体中加速TMA.
COVID-19还可以引发导致TMA的自身免疫性疾病.
针对性治疗方法对于COVID-19相关的TMA至关重要,考虑到其多样化的病理生理学.

关键词:

在 COVID-19 疫情中,急性脏损伤急性脏损伤是什么非典型的血液溶解尿素性尿性综合征.病理生理学病理生理学血栓性微血管病变是一种血栓性微血管病变.血栓性血栓细胞低血压性紫外线

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