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Spinal Cord: Cross-sectional Anatomy

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray...

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Updated: Jun 6, 2025

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

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Published on: September 23, 2015

追踪ALS退化:从脊髓和皮质转录组的见解

Nela Pragathi Sneha¹, S Akila Parvathy Dharshini¹, Y-H Taguchi²

¹Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, Tamilnadu, India.

|November 27, 2024

概括

研究人员确定了共享的分子途径在肌缩侧面硬化 (ALS) 影响额叶皮和脊髓. 上调的免疫反应和下调的代谢过程是神经退行症的关键,提供潜在的治疗点.

关键词:

这就是ALS.基因表达的基因表达方式网络网络网络网络网络网络神经退行性疾病的神经退行性疾病转录组分析转录组分析

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Revealing Neural Circuit Topography in Multi-Color

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科学领域:

神经科学是一个神经科学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,导致运动神经元损失.
在ALS中神经元死亡与线粒体功能障碍,氧化应激和兴奋毒性有关.
额叶皮和脊髓对于运动控制和功能至关重要.

研究的目的:

为了研究ALS中前额叶皮和脊髓的转录组数据.
确定ALS中常见的病理机制和途径.
发现ALS的潜在治疗点.

主要方法:

基因和转录表达模式被量化.
计算工具被用来预测变体和评估功能影响.
进行了功能相互作用网络和基因丰富分析.

主要成果:

发现了参与免疫反应上调的新基因.
在这两种组织中,与代谢相关的和缺陷的降解过程都被降低了.
基因调节和血压相关的基因在额叶皮层失调.

结论:

突出了ALS中明显和共享的分子干扰.
免疫反应和代谢功能障碍在神经元退化中起着至关重要的作用.
针对已识别的途径可能为ALS提供新的治疗策略.