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带有益生菌的细菌纤维素作为对抗抗卡巴耐药细菌感染的替代方案

José Gutiérrez-Fernández¹, Laura Cerezo-Collado², Víctor Garcés²

¹Department of Microbiology, Virgen de las Nieves University Hospital, 18014 Granada, Spain.

Antibiotics (Basel, Switzerland)

|November 27, 2024

概括

将益生菌纳入细菌纤维素中,可以产生抑制抗生素耐药细菌的活体生物材料. 这些新材料提供了一种稳定,持久的解决方案来对抗关键的病原体.

科学领域:

微生物学微生物学
生物材料科学生物材料科学
传染性疾病传染性疾病

背景情况:

抗生素耐药细菌 (ARB) 构成了严重的全球健康威胁,需要新的治疗策略.
世界卫生组织 (WHO) 将耐卡巴尼姆细菌确定为关键病原体.
开发新的抗菌药物是对抗由碳烯耐药细菌引起的感染的优先事项.

研究的目的:

开发用于对抗抗生素耐药细菌 (ARB) 的新型生物材料.
研究带有益生菌的细菌纤维素 (BC) 作为替代治疗方法的潜力.
为了评估BC中纳入的*Lactobacillus plantarum* (Lp) 和*Lactobacillus fermentum* (Lf) 对抗卡巴耐药细菌的疗效.

主要方法:

将 *Lactobacillus plantarum* (Lp), *Lactobacillus fermentum* (Lf) 和两者混合物纳入细菌纤维素 (BC) 中.
测试这些含有益生菌的BC材料对抗抗卡巴胺耐药肠道细菌 (CRE) 的疗效,例如*Klebsiella pneumoniae*和*Enterobacter cloacae*以及*Pseudomonas aeruginosa*.
评估单独的益生菌与被纳入BC矩阵中的益生菌的活性.

主要成果:

含有益生菌的细菌纤维素有效地抑制了三种ARB菌株的增殖,包括两种耐卡巴胺的肠细菌 (CRE) 和一种耐卡巴胺的Pseudomonas aeruginosa.
益生菌 (*L. plantarum*, *L. fermentum*,以及它们的混合物) 在被纳入BC.当中显示出抗菌活性增加.
生物材料表现出增强的稳定性,维持细菌活动长达两个月.

结论:

在细菌纤维素基质中由益生菌形成的生物材料表现出对ARB的增强抗菌活性.
该BC矩阵显著提高了*Lactobacillus*物种对抗抗卡巴胺耐药病原体的抗菌疗效.
这些含有益生菌的BC材料代表了对抗抗生素耐药性关键感染的有希望,稳定和长期的战略.

关键词:

细菌纤维素的细菌纤维素.生活物质生活物质生活物质益生菌是一种益生菌.耐药细菌是一种耐药细菌.

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