从爆发到持续释放:将抗生素结构纳入基托基膜的效果
Nathália F Sczesny1, Helton J Wiggers1, Cecilia Z Bueno1
1Laboratory for Biomaterials and Bioengineering (LBB-BPK), Associação de Ensino, Pesquisa e Extensão BIOPARK, Max Planck Avenue, 3797, Building Charles Darwin, Toledo 85919-899, PR, Brazil.
Antibiotics (Basel, Switzerland)
|November 27, 2024
概括
装有不同抗生素的新型基托桑基膜提供可调节的,延长释放的治疗医疗器械感染. 这种方法减少了抗生素的使用和耐药细菌的风险,提高了患者的安全.
科学领域:
- 生物材料科学 生物材料科学
- 传染病研究 传染病研究
- 药物输送系统 药物输送系统
背景情况:
- 医疗器械容易受到细菌殖民和生物膜的形成,导致严重的感染和增加医疗保健成本.
- 抗菌膜可以防止生物膜的形成,减少抗生素的使用和抗生素耐药性的出现.
- 之前的工作建立了 gentamicin 装载的奇托-酸薄膜;本研究探索其他抗生素.
研究的目的:
- 为了研究从基托基膜中释放的五种不同的抗生素 (莫西,西普罗,trimethoprim,硫,linezolid) 的释放行为.
- 评估这些带有抗生素的薄膜的抗菌活性和细胞毒性.
- 为了确定抗生素结构是否影响可调节药物输送的释放动力学.
主要方法:
- 基托桑基膜装满了五种不同的抗生素.
- 描述包括厚度,胀,质量损失和显微镜 (SEM,光学相位对比).
- 使用HPLC量化了抗生素释放,通过磁盘扩散测试了抗菌活性,并在人类皮肤纤维细胞上测试了细胞毒性.
主要成果:
- 抗生素的释放有显著的变化,从一天到六个月,允许分类到突发/暂时或延长释放的配置文件.
- 片对常见的医疗器械细菌表现出抗菌活性,并被发现是非细胞毒性.
- 纳入的抗生素的结构直接影响了释放动力学和抗菌功效.
结论:
- 抗生素结构是控制基托基膜释放药物的关键因素.
- 可以通过选择特定的抗生素来实现可调节释放配置文件,从而实现量身定制的抗菌涂层.
- 这些膜有可能在医疗器械中进行可扩展的应用,以减少生物材料相关感染 (BAI).
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