口腔状细胞癌的口腔微生物变化:专注于Treponema denticola,Lactobacillus casei和Candida albicans,这些细菌的特点是:
Yeon-Hee Lee1, Junho Jung2, Ji-Youn Hong3
1Department of Orofacial Pain and Oral Medicine, Kyung Hee University Dental Hospital, #613 Hoegi-dong, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Medicina (Kaunas, Lithuania)
|November 27, 2024
概括
口腔状细胞癌 (OSCC) 与Treponema denticola,Lactobacillus casei和Candida albicans的水平增加有关. 这些关键的口腔病原体显示出强烈的正相关性,这表明在OSCC发育过程中存在复杂的相互作用.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 口腔健康 口腔健康
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 口腔微生物组在维持口腔健康和疾病发展方面发挥着至关重要的作用.
- 识别与OSCC相关的特定微生物特征可以帮助早期检测和诊断.
研究的目的:
- 在OSCC.患者中调查特定口腔细菌和真菌的存在和丰富性.
- 探索关键口腔病原体及其在OSCC中的潜在作用之间的相关性.
- 为了区分健康个体,口腔炎患者和OSCC患者之间的微生物概况.
主要方法:
- 预计将12名参与者招募到三个组:健康对照组,口腔炎组和OSCC组.
- 使用实时PCR分析非刺激的全唾液样本.
- 对14种主要口腔细菌物种和Candida albicans的DNA复制数量定量.
主要成果:
- 在Treponema denticola (T. denticola),Lactobacillus casei (L. casei) 和Candida albicans的丰度中观察到显著的差异.
- 在OSCC组中,T. denticola的数量最为丰富.
- L. casei和C. albicans从健康对照对口炎,然后对OSCC患者的趋势越来越大,这三种微生物之间存在显著的正相关性.
结论:
- T. denticola,L. casei和C. albicans与口腔状细胞癌显著相关.
- 这三个口腔微生物在OSCC环境中相互表现出强烈的正相关性.
- 需要进一步的研究,以了解有助于OSCC发展的复杂微生物相互作用.
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