在立陶宛儿科三级护理中心的儿童多系统炎症综合征 (MIS-C)
Indrė Stacevičienė1, Inga Ivaškevičienė1, Odeta Kinčinienė1
1Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
Medicina (Kaunas, Lithuania)
|November 27, 2024
概括
儿童多系统炎症综合征 (MIS-C) 症状和实验室标记因年龄而异. 严重的病例通常具有高CRP,PCT,BNP和低白蛋白,但心血管问题通常会迅速解决.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 儿童多系统炎症综合征 (MIS-C) 是一种与SARS-CoV-2相关的严重疾病.
- 了解MIS-C的临床和实验室特征对于有效管理至关重要.
研究的目的:
- 分析MIS-C患者的临床和实验室特征,按年龄组和ICU入院分层分类.
- 评估儿科MIS-C患者的早期心声学变化.
主要方法:
- 2020年12月至2024年6月的一项单中心观察队列研究 (追溯和前性).
- 包括42名被诊断患有MIS-C的儿科患者 (1个月至18岁).
- 评估临床症状,实验室标志物和心声回声检查结果.
主要成果:
- 主要症状包括心血管 (88.1%),粘膜皮肤 (85.7%) 和胃肠道 (76.2%).
- 青少年表现出较少的粘膜皮肤/心血管症状,但表现出较高的前素 (PCT) 和较低的估计膜过率.
- 集中治疗室患者有更多的心血管/呼吸系统症状,较高的CRP,PCT,BNP和较低的白蛋白. 在71.4%的病例中存在心声学异常,在住院期间左心室喷射率显著改善.
结论:
- 在儿童年龄组之间,MIS-C表现和实验室发现有很大的差异.
- 较高的C-反应蛋白 (CRP),PCT,B型尿素 (BNP) 和低albuminemia可以预测MIS-C的严重程度.
- 虽然心血管干扰是常见的,并且可能是严重的,但早期心声图的改善提供了积极的前景.
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