血清VEGF-A水平是早期发作的中风后抑郁症的指标吗?
Emine Yildirim Uslu1, Sevler Yildiz2
1Department of Physical Medicine and Rehabilitation, Elazığ Fethi Sekin City Hospital, Elazığ 23280, Turkey.
Medicina (Kaunas, Lithuania)
|November 27, 2024
概括
血清血管内皮生长因子-A (VEGF-A) 水平没有预测急性缺血性中风患者的早期中风后抑郁症 (PSD). 认知和中风严重程度得分,而不是VEGF-A,与抑郁症严重程度相关.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 脑卒中后抑郁症 (PSD) 是一种常见的并发症,影响中风幸存者的生活质量.
- 了解早期PSD的生物标志物对于及时干预至关重要.
研究的目的:
- 研究血清血管内皮生长因子-A (VEGF-A) 水平与早期发病PSD之间的关系.
- 评估血清VEGF-A对急性缺血性中风 (AIS) 患者早期PSD的预测值.
主要方法:
- 88名AIS患者被评估为人口统计数据,临床特征和血清VEGF-A水平.
- 评估了神经缺陷 (NIHSS),认知功能 (MoCA) 和抑郁症严重程度 (HAMD-17).
- 损伤位置通过放射性成像确定.
主要成果:
- 与没有PSD的患者相比,PSD患者的MoCA得分较低,NIHSS得分较高.
- 在PSD和非PSD组之间没有观察到血清VEGF-A水平的显著差异.
- 血清VEGF-A水平与抑郁症严重程度 (HAMD-17) 或病变位置无关.
结论:
- 血清VEGF-A水平可能不是AIS患者早期发病PSD的可靠预测指标.
- 脑卒中严重程度 (NIHSS) 和认知障碍 (MoCA) 与抑郁症严重程度有关.
- 需要对更大的队列和对照组进行进一步的纵向研究.
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